PLENARY LECTURE: Variations in cancer risk

Assistant Professor, Johns Hopkins University
Cristian Tomasetti earned his Ph.D. in Applied Mathematics at the University of Maryland, College Park in 2010. He was then a postdoctoral fellow in the Department of Biostatistics of the Harvard School of Public Health, joint with the Department of Biostatistics and Computational Biology of the Dana-Farber Cancer Institute, until 2013, when he became an Assistant Professor in the Department of Oncology of the Johns Hopkins School of Medicine. He holds a joint appointment in the Department of Biostatistics of the Bloomberg School of Public Health, where he teaches the required first-year Graduate Probability Theory course for which he has received numerous teaching awards. Dr. Tomasetti is recognized internationally for his paradigm-shift contributions to the current understanding of cancer etiology and cancer evolution. He is also actively working on the development of novel methodologies for the estimation of cancer risk, as well as on the development of algorithms for the early detection of cancer.

SYMPOSIUM 1: Radiation-induced GI Syndrome

Cullen Taniguchi
MD Anderson
Jian Yu

SYMPOSIUM 2: Radiation dosimetry: In patients and phantoms
Mark Oldham
 Brian Pogue

SYMPOSIUM 3: Pre-clinical mechanisms of radiation immunotherapy
Andy Minn
U Penn
Elizabeth Repasky
Roswell Park
SYMPOSIUM 4: Hypofractionation: from pre-clinical models to clinical trials
Navita Somaiah
SYMPOSIUM 5: Genomics of normal tissue toxicity and tumor response to radiation
Kent Mouw
Mohamed Abazeed

SYMPOSIUM 6: Hypoxia and ER stress

Constantinos Koumenis

Marianne Koritzinsky
SYMPOSIUM 7: Imaging and circulation biomarkers of radiation response
Max Diehn
Andrew Wang
SYMPOSIUM 8: Radionuclides for imaging, therapy, and dosimetry
Ana Ponce Kiess
David Mankoff
uphs. upenn
Rebecca Abergel
Lawrence Berkely Laboratory
SYMPOSIUM 9: Chromatin biology and radiation response
Brendan Price

Tej Pandita, PhD
Houston Methodist

SYMPOSIUM 10: Space radiation and cancer risk
 Mike Weil
Colorado State
 Sylvain Costes

James DeGregori
UC Denver
Timothy Chan
Joseph Deasy
Marjan Boerma
Scott Floyd
PLENARY LECTURE: Modeling cancer in the mouse

Tyler Jacks, PhD
Director, Koch Institute for Integrative Cancer Research
Dr. Tyler Jacks is a world leader in the field of cancer genetics and is known for his ground-breaking work on the development of genetically-engineered mouse models of cancer (GEMMs). Over the course of his academic career, he has published over 200 peer- reviewed papers along with numerous review articles and book chapters. Dr. Jacks graduated magna cum laude with a BA in Biology in 1983 from Harvard College before becoming a graduate student in the laboratory of Dr. Harold Varmus at the University of California, San Francisco, where he showed that ribosomal frameshifting during translation gives rise to the gag-pol protein of the Rous sarcoma virus, HIV-1 virus and mouse mammary tumor virus. He went on to demonstrate that a stem-loop structure and RNA sequence making up the frameshift site are required for efficient frameshifting in vitro. In 1998, Dr. Jacks returned to Cambridge, Massachusetts, to join Dr. Robert Weinberg’s group as a post-doctoral fellow at the Whitehead Institute, where he developed several GEMMs, including the Rb, p53 and Nf1 mice. In 1992, Dr. Jacks became an assistant professor in the MIT Department of Biology and a member of the MIT Center for Cancer Research, which became the Koch Institute for Integrative Cancer Research at MIT in 2011. Currently, he is the David H. Koch Professor of Biology, Director of the Koch Institute for Integrative Cancer Research at MIT and an Investigator at the Howard Hughes Medical Institute. The Jacks lab has focused on developing new methods for the construction and characterization of GEMMs of human cancer. His group has produced GEMMs with constitutive and conditional mutations in several tumor suppressor genes, oncogenes, and genes involved in cell cycle control and apoptosis. Using these strains, the laboratory has developed models of various human tumor syndromes and cancer types, including Li-Fraumeni Syndrome, neurofibromatosis type 1, astrocytoma, retinoblastoma, pancreatic cancer, invasive colon cancer, soft tissue sarcoma, endometriosis, ovarian cancer and lung adenocarcinoma. These GEMMS have been used to examine the mechanism of tumor initiation and progression, to uncover the molecular, genetic and biochemical relationship to the human diseases, as tools to study response and resistance to chemotherapy, and to explore methods in molecular imaging and early detection of cancer. His laboratory has also extensively studied human tumor-derived cells, determined protein function in these cells, and related gene expression patterns in human cancers to their studies in mouse models. Novel pathways and processes that are critical for the progression of cancer have been discovered during these investigations.

In recent years, the Jacks lab has moved into the burgeoning area of tumor immunology and utilizing GEMMs to understand the interactions between the immune system and cancer. In particular the lab has developed a mouse model of lung adenocarcinoma that harbors mutations in the Kras and p53 genes and that also expresses model T cell antigens, which serve as targets for tumor-specific T cells and stimulate anti-tumor immune responses. These models offer a unique platform for investigating how anti-tumor immune responses shape tumor gene expression, and importantly how tumor evasion mechanisms contribute to the development of advanced disease. Moreover, they are invaluable preclinical models for testing immunotherapeutics, as single agents, or in combinations with traditional or targeted therapies.

Dr. Jacks has received numerous awards and honors for his contributions to the study of cancer genetics including the AACR Outstanding Achievement Award, the Amgen Award from the American Society of Biochemistry and Molecular Biology, the Chestnut Hill Award for Excellence in Medical Research, the Paul Marks Prize for Cancer Research, the Hope Funds for Cancer Research Award for Excellence and the Sergio Lombroso Award in Cancer Research. He was also a 2013 honoree of the MGH Cancer Center’s One Hundred celebration. Dr. Jacks served both as Chair and Member of the National Cancer Advisory Board at the National Cancer Institute as well as a member on the Board of Directors of the American Association for Cancer Research (AACR), where he was elected President of the organization in 2009. Dr. Jacks was also elected to the National Academy of Sciences, the Institute of Medicine of the National Academies, the American Academy of Arts and Sciences and the inaugural class of Fellows of the AACR Academy. Dr. Jacks serves as an advisor to several biotechnology and pharmaceutical companies. In 2015, he was the recipient of the Killian Award, the highest honor the MIT faculty can bestow upon one of its members. He is currently serving as director of the Blue Ribbon Panel for the National Cancer Moonshot Initiative, a working group of the National Cancer Advisory Board that provides expert advice to the task force lead by former Vice-President Biden.

SYMPOSIUM 11: Mechanisms of cell death after radiation
Kristopher Sarosiek
hsph harvard
Daohang Zhou
SYMPOSIUM 12: Dose rate and radiation toxicity
Marie-Catherine Vozenin
Peter Maxim
Aniek Janssen, PhD
Lawrence Berkeley National Lab
Samuel Bakhoum, MD, PhD
Memorial Sloan Kettering
Mitchell Turker, PhD, JD
Oregon Institute of Occupational
Health Sciences
Michael Hendzel, PhD
University of Alberta 
James W. Tunnell, PhD
University of Texas MD
Anderson Cancer Center
Sunil Krishnan, MD, FACP
University of Texas
Jan Schuemann, PhD
Massachusetts General
Peter Nelson, MD
University of Washington Medicine
Felix Feng, MD
University of California
Rob Bristow, PhD, FRCPC
Ontario Cancer Institute,
University of Toronto
Laure Marignol, PhD
Trinity College Dublin
 Mark Little, PhD
National Institute of Health-
Radiation Epidemiology
 Meetha Medhora, PhD
edical College of Wisconsin
 Daniel A. Mulrooney, MD, MS
St. Jude- Oncology & Epidemiology/
Cancer Cntrol Departments
Weng-LangYang, PhD
Feinstein Institute for Medical Research 
Ricky Sharma, MA, PhD, FRCP, FRCR
University of Oxford
Yaacov Lawrence, MD
Sheba-Tel HaShomer Hospital,
Thomas Jefferson University
Jeff Buchsbaum, MD, PhD, AM, DABR
National Cancer Institute
Kelly Falls, PhD
University of Iowa 
 Sunil Advani, MD
Moores Cancer Center, UC San Diego

Juliann Kiang, PhD
Uniformed Services University of the Health Sciences, Armed Forces Radiobiology Research Institute
Jackie Williams, PhD
University of Rochester Medical Center
R. Joel Lowy, PhD
Uniformed Services University of the Health Sciences
John Moulder, PhD
Emeritus- Medical College of Wisconsin
  Igor Koturbash, MD, PhD
Dr. Igor Koturbash is an Assistant Professor at the Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR. He received his MD (wit
Marie-Catherine Vozenin, PhD, HDR
Centre Hospitalier Universitaire
Harry Cullings, PhD, MS
Radiation Effects Research
Marianne Koritzinsky, PhD
University of Toronto
Dorthe Schaue, PhD
David Geffen School of
Medicine- UCLA

Professor Mary Helen Barcellos-Hoff, PhD
Dr. Barcellos-Hoff received an undergraduate degree from the University of Chicago and earned a doctoral degree in experimental pathology from the University of California, San Francisco. She condtherapy and is also interested in application of systems biology approaches to problems in radiation research.

Gillies McKenna, MD
University of Oxford
Eileen Connolly, MD, PhD
New York Presbyterian/Columbia University Medical Center
Simon Powell, MD, PhD
Memorial Sloan Kettering Cancer Center
Jennifer Yu, MD, PhD
Lerner Research Institute of Cleveland Clinic

John Ng, MD
New York Presbyterian,
Weill Cornell University

Noriko Koganezawa, PhD
Gunma University Graduate
School of Mdicine
 Roman Vlkolinsky, PhD
School of Medicine at
Loma Linda Unversity
Murat Alp, PhD
University of Nevda

Shogo Ishiuchi, MD, PhD
Univerity of Ryukys

 Tayyaba Hasan, PhD
Harvard Medical School,
Massachusetts General Hospital
Samuel Achilefu, PhD
Washington University
School of Medicine
Lei Xing, PhD
Standford Medicine 
Premkumar Saganti, PhD
Prairie View
A & M University
Nalinikanth Kotagiri, PhD
University of Cinncinati 
Jan Grimm, MD, PhD
Jan Grimm Lab- Memorial Sloan
Kettering Cancer Center
Gabriel Sawakuchi, PhD
MD Anderson Cancer Center 

James Gulley, PhD
National Cancer Institute Center for Cancer Research
Roger Howell, PhD
Rutgers NJ Medical School
Roger Martin, PhD
Peter MacCallum Cancer Centre
Robert Hobbs, PhD
Johns Hopkins Medicine
David Yu, MD, PhD
Emory University School of
Medicine, Grady Memorial Hospital
David Brenner, MD, PhD
Center for Radiological
Chuan-Yuan Li, DSc
Duke University School of Medicine
Erina Vlashi, PhD
UCLA- Radiation Oncology

John Tainer, PhD
John Tainer has studied biologically-interrelated stress responses for reactive oxygen, immune activation, pathogenicity, ionizing radiation, and DNA damage for more than 25 years. He gradu

Frank Pajonk, MD, PhD
UCLA- Radiation Oncology
Kerry O’Banion, MD, PhD
University of Rochester
Medical Center

Marcelo Wood, PhD
University of California- Irvine

Munjal Acharya, PhD, MS
University of California- Irvine
FOR: Mike Joiner, PhD
Wayne State University
AGAINST: Martin Brown, PhD, MSc
Emeritus- Stanford Medicine
Jim Welsh, MD
MD Anderson Cancer Center 
Steven Chmura, MD, PhD
University of Chicago Medicine
Janet Horton, MD
Duke Cancer Center
Weiguo Zhang, MD, MSc, PhD
Lawrence Berkeley National Laboratory

Daniel Stram, PhD
University of Southern California
Eric Grant, PhD
Radiation Effects Research
Christian Kaiser, PhD
Institute of Radiation Protection-
German Research Center for
Environmental Health
Christophe Badie, PhD, MSc
Public Health England’s Centre for
Radiation, Chemical and Environmental
Norman Coleman, MD
National Cancer Institute Center for Cancer Research
Eric Chuang, Sc.D
National Taiwan University- Yonglin Biomedical Engineering Center
Naduparambil Jacob, PhD
Ohio State University Comprehensive Cancer Center
Molykutty J Aryankalayil, PhD
National Cancer Institute Center for Cancer Research
Sanchita P.Ghosh, PhD
Uniformed Services University of the Health Sciences
Nicole L. Simone, MD
Jefferson Health
Brian Marples, PhD
University of Miami Health Systems
Giuseppe Schettino, PhD
National Physical Laboratory
Ke Sheng, PhD, DABR
UCLA- Department of
Radiation Oncology


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